His research currently focuses on the connections between cancer and normal developmental processes and on the use of genomic technologies to identify pathways that are active in tumors and that may serve as therapeutic targets. Luis Mgh is on Facebook. We use cookies and other tools to enhance your experience on our website and Learn about career opportunities, search for positions and apply for a job. For more information about these cookies and the data Cancer Discovery 2017 Mar 7(3):288-301. Our laboratory uses genomic technologies to identify abnormal gene regulation patterns in tumors and to analyze critical oncogenic pathways in several systems. “We set out to find the most important regulators of gene expression programs in medulloblastoma,” says senior author Miguel Rivera, MD, of the MGH Department of Pathology and the Center for Cancer Research. Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA. Our work using this technology has shown that Wilms tumors exhibit chromatin features typical of stem cells and that patterns of chromatin remodeling can reveal the mechanisms of action of aberrant transcriptional regulators such as the EWS-FLI1 fusion protein in Ewing sarcoma and the transcription factor OTX2 in medulloblastoma. Pathology. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Explore fellowships, residencies, internships and other educational opportunities. Dr. Rivera is a board certified pathologist who directs a research laboratory at the MGH Department of Pathology and the MGH Cancer Center. Anesthesia, Critical Care & Pain Medicine, Billing, Insurance & Financial Assistance, MGH Research Institute the focus of SAC meeting, Prion-Like Domains Drive Tumor Growth in Ewing Sarcoma, Miguel N. Rivera, MD, MGH Research Scholar Profile, Scientific Advisory Committee meeting focuses on challenges facing research faculty, Molecular Genetic Pathology, American Board of Medical Genetics, Anatomic Pathology, American Board of Pathology, Great-West Healthcare (formally One Health Plan). Download Full PDF Package. Join Facebook to connect with Miguel MG and others you may know. We are committed to providing expert care—safely and effectively. He graduated with honors from Harvard Medical School in 2001. Massachusetts General Hospital ... Miguel N Rivera. In particular, genome-wide chromatin profiling, which combines chromatin immunoprecipitation and high-throughput sequencing, is a powerful technology that can identify active and repressed states in the genome based on patterns of histone modifications. Sridhar Ramaswamy. Get the latest news on COVID-19, the vaccine and care at Mass General. In collaboration with Dr. Lee Zou, Drs. Let us help you navigate your in-person or virtual visit to Mass General. The MGH Dementia Care Collaborative will hold a two-part, Health and Resiliency series: September 10th & 24th from 1-2 pm presented by Miguel Rivera, MD. COVID as a Catalyst for Meaningful Conversations When Living With Dementia. With support from the Hyundai Hope on Wheels grant, the Rivera lab is working with a mouse model and directly with Wilms tumor tissue from patients to shed light on the role of WTX. We offer diagnostic and treatment options for common and complex medical conditions. The Registered Agent on file for this company is Rivera Miguel J and is located at 7815 Sw 8th Street, N. Lauderdale, FL 33068. 2 likes. Support the … Find a provider affiliated with Mass General Brigham, founded by Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital (BWH). In particular, his research focuses on how gene expression programs are altered in cancer. We are now studying the function of WTX and related proteins using several in vitro and in vivo model systems. 37 Full PDFs related to this paper. haber@helix.mgh.harvard.edu (D.A.H.) Miguel Rivera, M.D. Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network. Miguel N. Rivera 1, Nabeel Bardeesy 1, Shyamala Maheswaran 1, Daniel A. Haber 1, † 1 Massachusetts General Hospital Cancer Center and Departments of Medicine, Pathology, and Surgery, Harvard Medical School, Boston, MA 02114, USA. Find a Doctor; Hospitals & Locations; Log In to Patient Gateway; COVID-19. The Broad Institute’s faculty members are all faculty members of MIT, Harvard or one of the Harvard-affiliated hospitals. Miguel Rivera, MD ... Hannah Shefsky, Board-Certified Music Therapist Massachusetts General Hospital June 2020. 2 Helicos BioSciences Corporation, One Kendall Square, Cambridge, MA 02139, USA. Learn about the many ways you can get involved and support Mass General. The Broad Institute’s faculty members are all faculty members of MIT, Harvard or one of the Harvard-affiliated hospitals. Miguel Rivera, MD, is investigating how abnormalities in gene regulation in pediatric brain and bone cancers (medulloblastoma and Ewing sarcoma respectively) drive the growth of these tumors. Investigator: Sabina Signoretti, MD and Holger Moch, MD (BWH) Tel. 02129, Program Affiliations MGH Pathology Service Center for Cancer Research. Miguel Rivera, MD* Assistant Professor of Pathology, Harvard Medical School, Massachusetts General Hospital Cancer Center. A short summary of this paper. 2010 Jun 4;6(6):591-602. For more information about these cookies and the data OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma. Medicine Cabinet Mayhem. Miguel Rivera, MD, receives a handprint from a patient during the Hyundai Hope on Wheels Handprint Ceremony for research on childhood cancer. We have remained at the forefront of medicine by fostering a culture of collaboration, pushing the boundaries of medical research, educating the brightest medical minds and maintaining an unwavering commitment to the diverse communities we serve. The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in … 7 - 17 Uhr: 0621 1703-2150 Tel. The newly identified gene is mutated in about 30 percent of cases of Wilms tumor and is located on the sex-determining X chromosome, which means that a single altered copy would be sufficient for tumor formation. Miguel Rivera Wilms tumor is the most common childhood kidney cancer, afflicting roughly 500 children in the United States each year. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Miguel Rivera and Gregory Cote are working on several different research projects to advance our understanding of and treatments for these rare sarcomas. Massachusetts General Hospital researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor. Juliet Jacobsen, MD Massachusetts General Hospital April 2020. They are full citizens of their home institutions – including having full teaching and other responsibilities. Using a high-resolution screen for DNA copy-number alterations in Wilms tumor, we identified somatic deletions targeting a previously uncharacterized gene on the X chromosome. Cell Stem Cell. Matteo Ligorio. The General Hospital Corporation. Through mapping genomic deletions in Wilms tumor we identified WTX, an X-linked tumor suppressor gene commonly inactivated in this disease and recently implicated in colon cancer. Miguel Lindström is on Facebook. s Hospital and a fellowship in Molecular Diagnostics at the Harvard Combined Program. This paper. 149 13th St Charlestown , MA : (617) 726-4354 Locations & Directions Ting et al. In most cases, surgery combined with chemotherapy can kill these cells, but not all cases of Wilms tumor respond to current therapies. We use cookies and other tools to enhance your experience on our website and Given that the mechanisms that drive pediatric tumors are poorly understood at present, we anticipate that our work will point to new therapies for these diseases. Massachusetts General Hospital Cancer Center Charleston, MA Function of the protein kinase VRK1 in Ewing Sarcoma Funded by the Stuart Scott Memorial Fund. Molecular Pathology UnitMassachusetts General Hospital149 13th Street, 6th Floor The Broad faculty consists of … Search for condition information or for a specific treatment program. Log In Massachusetts General Hospital (MGH) ... We set out to find the most important regulators of gene expression programs in medulloblastoma,” says senior author Miguel Rivera, MD, of the MGH Department of Pathology and the Center for Cancer Research. Close. Colorectal cancers (CRCs) harboring KRAS or BRAF mutations are refractory to current targeted therapies. Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN. collected, please refer to our Privacy Policy. NOTES: - "Affiliation" is the local physician organization to which the doctor belongs. Copyright © 2007-2021. Wilms tumor, the most common pediatric kidney cancer, arises from kidney-specific stem cells and is a prime example of the connection between cancer and development. 2 Helicos BioSciences Corporation, One Kendall Square, Cambridge, MA 02139, USA. 7 Massachusetts General Hospital Cancer Center,Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; dhaber@mgh.harvard.edu. Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA (2007). Chromatin remodeling proteins are frequently dysregulated in human cancer, yet little is known about how they control tumorigenesis. Notfall. aryee.martin@mgh.harvard.edu (M.J.A. Abstract. Anesthesia, Critical Care & Pain Medicine, Billing, Insurance & Financial Assistance. The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity. Learn about the many ways you can get involved and support Mass General. EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. Rivera MN, Haber DA (2005) Wilms tumor: connecting tumorigenesis and organ development in the kidney. Given that the mechanisms that drive pediatric tumors are poorly understood at present, we an… Miguel Rivera, MD, MGH Sandro Santagata, MD, PhD, BWH Shiladitya Sengupta, PhD, BWH Paul Shyn, MD, BWH Matthew Steinhauser, MD, BWH Shannon Stott, PhD, MGH Mario Suva, MD, PhD, MGH David Ting, MD, MGH DISCOVERY CAFÉ LUNCH Enjoy Lunch with … We have remained at the forefront of medicine by fostering a culture of collaboration, pushing the boundaries of medical research, educating the brightest medical minds and maintaining an unwavering commitment to the diverse communities we serve. Our laboratory uses genomic technologies to identify abnormal gene regulation patterns in tumors and to analyze critical oncogenic pathways in several systems. Aberrant phase separation allows the protein to build up in these areas. have utilized a micro- fluidic device to perform single-cell RNA sequencing of pancreatic CTCs, identi-fying three distinct populations that sug-gest multiple paths in the metastatic cascade. If you need immediate assistance, call 877-SSRNHelp (877 777 6435) in the United States, or +1 212 448 2500 outside of the United States, 8:30AM to 6:00PM U.S. Eastern, Monday - Friday. Wilms tumor is a pediatric kidney cancer associated with inactivation of the WT1 tumor-suppressor gene in 5 to 10% of cases. Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.Aiden AP, Rivera MN, Rheinbay E, Ku M, Coffman EJ, Truong TT, Vargas SO, Lander ES, Haber DA, Bernstein BE. Safe Care CommitmentGet the latest news on COVID-19, the vaccine and care at Mass General.Learn more. Ivan Stamenkovic,4 Cigall Kadoch,2,3,7,* and Miguel N. Rivera1,3,5,7,8,* 1 Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA 2 Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA General research team shows a mechanism that controls the expression of important genes in medulloblastoma Science, 315: 642-5. This gene, which we call WTX , is inactivated in approximately one-third of Wilms tumors … Read more about the Rivera Lab. Aberrant phase separation allows the protein to build up in these areas. by MGH molecular pathologist Miguel Rivera identified11 a protein implicated in Ewing’s sarcoma that provokes activity in cancer-causing genes when it gathers near pieces of the genome linked to tumour formation. Download with Google Download with Facebook. Safe Care CommitmentGet the latest news on COVID-19, the vaccine and care at Mass General.Learn more. During his postdoctoral fellowship, Dr. Rivera identified the tumor suppressor gene WTX which is implicated in both tumor formation and stem cell biology. - A primary care provider (or PCP) is a doctor or in some cases, a nurse practitioner or physician assistant, who sees patients for everyday medical issues, such as colds and annual wellness visits. Center for Cancer Research Annual Report. Practice Locations: Boston, MA. or. We are committed to providing expert care—safely and effectively. Using genomics to identify critical pathways in pediatric tumors. WTX is the founding member of a new protein family (FAM123) and our work using a conditional knockout mouse model has shown that it regulates mesenchymal stem cells in several organs, including kidneys, bones and fat. Join Facebook to connect with Miguel Lindström and others you may know. Let us help you navigate your in-person or virtual visit to Mass General. 6 Center for Bioengineering in Medicine, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, MA 02114. A pathologist is a physician who specializes in the causes and paths taken by different diseases in order to accurately diagnose an illness. Here, we uncover an epigenetic program mediated by the NAD(+)-dependent histone deacetylase Sirtuin 6 (SIRT6) that is critical for suppression of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignancies. Miguel Ruiz. He graduated with honors from Harvard Medical School in 2001. Total downloads of all papers by Miguel N. Rivera. Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted. Secure online access to your health information whenever you need it. Copyright © 2007-2021. Nabeel Bardeesy. He completed his Anatomic Pathology residency at Brigham and Wome? Alterations in transcriptional regulators can orchestrate oncogenic gene expression programs in cancer. Jon C. Aster, M.D., Ph.D., Professor of Pathology, Brigham and Women’s Hospital, "Notch signaling in cancer” (https://connects.catalyst.harvard.edu/Profiles/display/Person/48586) Bradley Bernstein, MD, PhD; Professor of Pathology, MGH,“Chromatin biology and cancer epigenetics” (http://bernstein.mgh.harvard.edu/) Ruben D. Carrasco, MD, PhD; Associate professor of Pathology, Dana-Farber Cancer Institute, “Functional characterization and targeting of oncogenic pathways in mouse mo… Here we show that the BAF chromatin-remodeling complex, which is mutated in over 20% of human tumors, interacts with EWSR1, a member of a family of proteins with prion-like domains (PrLD) that are frequent partners in oncogenic fusions with transcription factors. Get the latest news on COVID-19, the vaccine and care at Mass General. Miguel N. Rivera, MD, MGH Research Scholar Profile. Debattama Sen, PhD Member of the Faculty, Massachusetts General Hospital Cancer Center, Harvard Medical School. Nicola Aceto. Investigator: Daniel Haber MD, PhD and Miguel Rivera, PhD (MGH) A Genetic Model for Target Identification in VHL-HIF Signaling. Nature Genetics, 36(9):949-51. Assistant Molecular Pathologist, Massachusetts General Hospital. We offer diagnostic and treatment options for common and complex medical conditions. The genetic abnormality that drives the bone cancer Ewing sarcoma operates through two distinct processes -- both activating genes that stimulate tumor growth and suppressing those that should keep cancer from developing. Chromatin remodeling proteins are frequently dysregulated in human cancer, yet little is known about how they control tumorigenesis. ), dting1@mgh.harvard.edu (D.T.T.) Explore fellowships, residencies, internships and other educational opportunities. Cancer Cell. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. Pediatric tumors are often driven by mutations in genes that directly control gene expression programs such as transcription factors and chromatin regulators. Dr. Rivera received an A.B. Read more about the Rivera Lab from the Center for Cancer Research Annual Report. Join Facebook to connect with Luis Mgh and others you may know. Detection of large-scale variation in the human genome. Specialties Dr. Miguel Rivera has the following 2 specialties . Dr. Rivera is the attending physician in the Center for Integrated Diagnostics. Mass General is the #1 Research Hospital in America and the only hospital to be recognized in all 16 specialties assessed by U.S. News & World Report. Read More About Dr. Rivera’s Research Dr. Miguel N Rivera is a Pathology Specialist in Charlestown, Massachusetts. Charlestown, Miguel N. Rivera 1, Nabeel Bardeesy 1, Shyamala Maheswaran 1, Daniel A. Haber 1, † 1 Massachusetts General Hospital Cancer Center and Departments of Medicine, Pathology, and Surgery, Harvard Medical School, Boston, MA 02114, USA. Boulay G, Sandoval GJ, Riggi N, Iyer S, Buisson R, Naigles B, Awad ME, Rengarajan S, Volorio A, McBride MJ, Broye LC, Zou L, Stamenkovic I, Kadoch C, Rivera MN. Miguel MG is on Facebook. The company's filing status is listed as Active and its File Number is P15000097986. collected, please refer to our Privacy Policy. Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. The 70th meeting of the MGH Scientific Advisory Committee focused on the MGH Research Institute, which was founded in 2015 as an organizational home for the more than 8,500 MGHers in 30 departments, centers and institutes who make up the largest hospital-based research program in the U.S. How the EWS-FLI1 fusion protein promotes tumor formation in Ewing Sarcoma is not fully understood and is the focus of new research from the lab of Miguel N. Rivera, MD. Get the latest news, explore events and connect with Mass General. Please call Dr. Miguel Rivera's office for more information. MGH Scientific Advisory Committee April 3 & 4, 2019 Simches Auditorium 185 Cambridge Street, 3rd Floor SAC 2019 Poster Session Abstracts. Miguel Rivera. Boulay G, Awad M, Riggi N, Archer T, Boonseng W, Rosetti N, Naigles B, Volorio A, Iyer S, Kim J, Mesirov JP, Tamayo P, Pomeroy SL, Aryee MJ, Rivera MN. 8:30 - 17:00 Uhr Telefon: 0621 1703-2850 E-Mail: zentralambulanz@zi-mannheim.de. Miguel Rivera, MD, is investigating how abnormalities in gene regulation in pediatric brain and bone cancers (medulloblastoma and Ewing sarcoma respectively) drive the growth of these tumors. Molecular 'on switch' could point to treatments for pediatric brain tumor Mass. to analyze our web traffic. Pathology Research activities occupy approx. 2007 Feb 2;315(5812):642-5. Get the latest news, explore events and connect with Mass General. MA  At Mass General, the brightest minds in medicine collaborate on behalf of our patients to bridge innovation science with state-of-the-art clinical medicine. Specialties: Anatomic Pathology, Clinical and Laboratory Pathology. 17 - 7 Uhr: 0621 1703-0 Dr. Miguel N Rivera is a Pathology Specialist in Charlestown, Massachusetts. The Broad faculty consists of Miguel Rivera: MGH: 2008: Burroughs Wellcome Career Award for Medical Scientists: Robert Plenge: MGH: 2008: Burroughs Wellcome Career Award for Medical Scientists: Daniel Cahill: MGH: 2008 : Burroughs Wellcome Career Award for Medical Scientists: Ananth S. Karumanchi: BIDMC: 2008: Burroughs Wellcome Career Award for Medical Scientists: Catherine Wu: DFCI: 2007: Damon Runyon … Miguel Rivera, M.D., from Massachusetts General Hospital aims to design new therapies for pediatric cancers by uncovering the biological mechanisms behind them. The Pathology Basic Science Research Brochure brochure highlights the basic scientific research activities in MGH Pathology. Nature Reviews Cancer, 5(9):699-712. Learn about career opportunities, search for positions and apply for a job. See more of Miguel Ruiz on Facebook. Using data from a high-throughput drug screen, we have developed a novel therapeutic strategy that combines targeting of the apoptotic machinery using the BCL-2 family inhibitor ABT-263 (navitoclax) in combination with a TORC1/2 inhibitor, AZD8055. Miguel N. Rivera, MD Massachusetts General Hospital Massachusetts General Hospital Phone: (617) 726-5695. mnrivera@partners.org. Proceedings of the National Academy of Sciences U S A, 106(20):8338-43. from Harvard Medical School in 2001.
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